There's no single ratio that's right for everyone. You'll want to find the balance of CBD and THC that works you. A person's sensitivity to THC is a key factor in finding the right ratio and dosage. Many people like the cannabis high. Others find THC unpleasant. CBD can lessen the mind-altering effects of THC, so, a greater ratio of CBD-to-THC (18:1) means less of a high. Care By Design offers several ratios of CBD:THC so you can adjust or eliminate psychoactive effects as you prefer. Some patterns are beginning to emerge. For anxiety, depression, spasms, psychosis, and seizure disorders, some people report they do best with little THC. For cancer, autism, and other diseases, some patients say they benefit more from a balanced ratio of CBD and THC like the 4:1 or 2:1. Extensive clinical trials conducted outside the United States have shown that a 1:1 CBD:THC ratio can be effective for neuropathic pain. Some people use cannabis products with different CBD:THC ratios at different times of the day, using for example more CBD in the day, more THC at night.